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And it would need to be demonstrated that regenerated ligaments were durable over time.
Overall, beyond task-specific effects (verbal content or complexity), for a coherent benefit to occur it would need to be demonstrated across measures of a construct.
Such positive effects on organ perfusion would need to be demonstrated by further specific studies; however, it does raise the possibility that a head-up position may be advantageous for reasons other than simple ventilatory mechanics.
This could mean that some type of inflammatory process is needed to induce the fibrotic process, possibly by causing enough apoptotic bodies to enhance TGF-β production, although this would need to be demonstrated experimentally.
Such beneficial effects may be present but they would need to be demonstrated in a randomized controlled trial.
An increase in maximum life span owing to manipulating PPARγ would need to be demonstrated before concluding definitively that it is involved in progression of aging.
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Given the expectation that such a medication--should it pan out--would need to be used "for a sustained period," he cautioned, its safety and continued effectiveness over the long term would also need to be demonstrated.
Even if some shedding were possible, it would still need to be demonstrated that this occurred commonly and resulted in the release of sufficient quantities of viable, infective virus to be of importance in field epidemiology.
The central role played by NO suggests that inhibition of inducible NOS expression would be beneficial but this needs to be demonstrated experimentally, especially because inhibition of endothelial NOS might worsen brain ischaemia.
"If that 300 is real," says Cairns, "that would be a significant improvement". But he says this performance needs to be demonstrated and verified by a third party.
That case is still one that needs to be demonstrated.
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