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While such germ cells may be able to undergo normal fertilization, the effect of such disregulation, in combination with continuing abnormalities during cell division, would lead to developmental delay, embryo abnormalities, and death at early post-implantation stages as seen in our study.
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Any alterations in the mitochondrial protein import pathway resulting from incompatibilities of heterogeneous mtDNA and genome DNA would likely lead to developmental failure of PBNT embryos.
In this example, the level of estrogen synthesized in the eggs is already sufficient to drive sexual differentiation at the temperatures typically encountered by this species; in other words, the level of endogenous estrogen under normal conditions for this species is already midway up the dose-response curve, and any change in estrogen levels would lead to changes in the developmental outcome.
Since the same molecular events are involved in development and developmental growth, this would lead to the reductio ad absurdum that development is caused by damage.
Increases in mRNA expression could arise either by selective upregulation of gene expression in females, or through developmental changes that would lead to an increase in the number of neurons expressing these receptors in females.
A better understanding of the developmental and environmental factors that control fruit set would lead to an optimization of growing conditions that might improve crop production.
Since the plants with maximum spot numbers display strong developmental retardation, it is likely that higher doses of DNA damage would lead to accumulation of mutations and apoptosis.
We hypothesized that drug exposures altering only acetylation would lead to reversible transcriptome changes (indicating MoA), and challenges that altered methylation would lead to irreversible developmental disturbances.
Topical JHA was applied to dl in varying doses and at different developmental time points in order to observe whether artificially increasing JHA titers would lead to the appearance of a wt phenotype in successive larval instars.
This delay would lead to a fitness loss sufficiently large for natural selection to act upon, since mutants with a developmental delay as small as 2.6 h can be outcompeted by wild-type organisms [ 41].
(Which would lead to fewer abortions anyway).
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