Sentence examples for would be refractory from inspiring English sources

Thus, we postulated that C/EBPβ−/− mice would be refractory to the induction of liver fibrosis.

The fosmid-cloning-based chloroplast genome sequencing approach described here allows chloroplast genomic analysis for algal species that would be refractory to conventional organellar DNA isolation and analysis.

The presence of DNA structures that would be refractory to DNA polymerase is indicated by our difficulty in amplifying across this region using conventional PCR.

We also reasoned that, unlike the 5' monophosphate termini of a fragmented transcript, primary RNA transcripts with a 5' triphosphate would be refractory to library preparation and sequencing (Additional file 1: Figure S5D) [ 25].

We tested this hypothesis by inducing HO-1, an inducible rate-limiting enzyme in heme catabolism implicated in host cellular defense, in MDM by LPS to determine whether HO-1-expressing MDM would be refractory to productive HIV-1 infection.

From the results of previous studies we postulated that uninfected cells could display a detrimental response to prolonged stimulation with an inflammatory mediator, while Theileria-infected cells would be refractory to such stimulation.

However the differences are not large; using the same criterion, 47.75% of annanassae clones, 53.58% of D. persimilis and 53.58% of D. pseudoobscura genes would also be refractory (Figure 1e).

Since no intermediates other than free radicals generated following energy deposition and their interaction with the DNA molecule are involved [32], [33], [34], it appears theoretically unlikely that heterochromatin would be very refractory to DSB generation by IR.

Validating these human orthologs as genes which confer resistance to DOX could allow strategies to be designed that sensitize DOX resistant cancers that would be normally refractory to treatment with this drug.

It is also well-known that cell cycle inhibition by p16INK4a is RB-dependent [ 48] and, therefore, these RB1-deficient breast tumours would be expected to be refractory to the high levels of p16INK4a.

If there is some form of long-range regulatory mechanism operating across the ParaHox genes, as clearly happens with the vertebrate Hox genes [ 60], then the organisation of the genome around the ParaHox genes would be expected to be refractory or intolerant to extensive rearrangements during evolution, as has been observed for genomic regulatory blocks (GRBs) in vertebrate genomes [ 61].