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Thus, we sought to examine whether the requirement for Dazl function would be recapitulated in the differentiation of mESCs to germ cells in vitro.
If enteric neurodegeneration occurs in the course of PD, the cardinal neuropathology of the disease, namely neuronal death and Lewy inclusions, would be recapitulated in the ENS, thereby mirroring the lesions of affected brainstem nuclei in the CNS.
We next determined whether the TEM kinetics we had observed in patients with CLI would be recapitulated in a mouse model of severe HLI that simulates CLI in man.
In this study, however, we hypothesized that the broad biological effects of metal chaperones that we have characterized in transgenic mouse models of AD (Adlard et al., 2008, 2011) would be recapitulated in normal aged mice.
These data suggest that mutation biases, which would be recapitulated by SNP mutations, do not account for the difference in GC* we observe when genomic regions displaying different background GC contents are analyzed; rather, such differences derive from diverse fixation probabilities.
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It should be noted that as the fast-evolving control region is known to be unreliable as a molecular clock (Ingman et al. 2000), the deeper relationships across haplogroups, reliably established using the full alignment, would not necessarily be recapitulated using only the control region.
As Doolittle [ 61] suggests, the critical point is that once coding evolved, the sequences of these noncoded proteins would have needed to be recapitulated by coded proteins; therefore the phylogenetic signal would only go back to the point of recapitulation.
If the CNSs are orthologous, we would expect that the species tree should be recapitulated with high statistical support.
In addition, it would be interesting to see whether ITL disruption can be recapitulated in progerin expressing wild type cells.
These strain characteristics could be recapitulated in vivo using this device, which would then enable direct testing of the osteogenic and chondrogenic strain hypotheses.
This episode is set up to be recapitulated at the end of the film.
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