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As accounting for these additional levels of regulation in multiple biopsies would be exceedingly challenging, targeting multiple tumor clones might best be accomplished using immunotherapy approaches such as tumor-lysate stimulated adoptive cell transfer or immune regulatory check point blockade agents such as ipilimumab.
An analogy that has often been used to emphasize the importance of visualization of living specimens is that reconstructing the basic rules and their consequences of a sports game such as football from a series of still images taken at different times from different games would be exceedingly challenging, if not impossible.
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Regions of high sensitivity to hydrolysis by α-amylase are crucial for amylolysis in nature, but characterization of these regions has proven to be exceedingly challenging.
There are particular circumstances that are exceedingly challenging both for the individual concerned and their family.
But under the $7 million exemption proposed by the Obama administration, such cases would be exceedingly rare.
In an interview, Mr. McKibben said he recognized that a rapid transition away from fossil fuels would be exceedingly difficult.
"It would be exceedingly odd if you only had one to put it on the driver's side," he added.
Such a crisis might lead to Korean unification but would be exceedingly dangerous in the short term.
Any attempt to derail this misbegotten move now would be exceedingly difficult.
Then ORFs longer than a few hundred bases would be exceedingly rare.
Ie. the number of cleavage events that would occur prior to turnover of soluble Aβ1 x would be exceedingly small.
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CEO of Professional Science Editing for Scientists @ prosciediting.com