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It could be argued that any difference in effect on the primary clinical outcome would be worth detecting.
It was decided, in line with other rigorous pragmatic studies that the smallest difference worth detecting was a 20% reduction in number of days with URTI".
We assume a mean difference of 400,000 counts per week between the intervention and control groups is the smallest difference of clinical and practical importance that is worth detecting.
Based on previous studies that have been done primarily in pregnant women, we chose an effect size of 0.15 SD as worth detecting from the point of view of public health significance.
An absolute reduction in 20% of all antibiotic use, which corresponds to a reduction in the proportion of antibiotic prescriptions for urinary indications from 30%to10%0%, was considered the minimal clinically important effect worth detecting.
Expiratory abdominal activity is worth detecting, underlining the importance of the development and validation of noninvasive, reliable and accurate markers of abdominal activity for an optimal setting of noninvasive CPAP in infants.
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It is worth noting that detecting misbehaving nodes among one-hop nodes is quite easy due to the broadcast nature of wireless communications.
In both cell lines only minimal caspase-3 cleavage could be detected, worth mentioning is the minor dose response detectable for the curve shift to the right within Cal-78 cells.
Worth mentioning, we detected expression of several pplps in the P. falciparum blood and gametocyte stages.
Assuming 70% compliance and 50% coverage of the colorectal mucosa by flexible sigmoidoscopy, we regarded a 30% reduction in incidence after five years in the intention to screen population as possible to achieve and definitely worth while to detect.
But it takes time for the technology to gain credibility and for states to decide whether detecting such rare diseases is worth the money.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com