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Worst prognostic factors are the tumour dimensions (more than 5 cm), a non-radical surgical resection, and the presence of distant metastasis.
When considering breast cancer irrespective of the ER or PgR expression status, CD138 expression is associated with the worst prognostic marker Her2/neu.
Moreover, previous studies have associated reduced miR-29c with p53 status and 17p deletion, the worst prognostic group in CLL [30], [31].
In the first case, AG1 was the worst prognostic group.
Consequently, triple-negative tumors have become the worst prognostic group since the emergence of trastuzumab.
Without chemotherapy, BLBCs were worst prognostic subtype in both DFS and OS.
Similar(31)
Interestingly, the ALCAM transcript number was lower in the worst NPI prognostic group (NPI > 5.4) when compared with the best prognostic group (NPI < 3.4) (P = 0.014) (Fig. 4d).
Among the four subgroup patients, the worst FOXM1 prognostic value for OS and RFS was observed in HPV 16/18 positive patients with tumors with high-expressing FOXM1.
The data were checked for duplicate records; women with bilateral cancers were recorded once and the pathology information (where available) for the cancer with the worst Nottingham Prognostic Index score used.
In particular, the synthesis of GM3/GD3 and of "a" complex gangliosides appeared to have a worst and good prognostic value, respectively.
From a clinical viewpoint, concomitant overexpression of HER2 and hMena identifies a subgroup of breast cancer patients showing the worst prognosis, indicating that hMena overexpression adds prognostic information to HER2 overexpressing tumors.
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