Consequently, but inevitably, it results in worsening of language social situations.
Analysis of the SIB-L-J in this study revealed that memantine was associated with less worsening of language function throughout the treatment period compared with placebo.
Taken together, the results appear to indicate that memantine is effective in the reduction of worsening of language ability in Japanese patients.
Most studies did not find a relationship, apart from two who found that a larger volume was associated with worsening of language and executive functioning [ 49, 64].
At week 24 (LOCF analysis), the NNT for patients with at least no worsening in language performance was 3.6 patients (those with baseline SIB-L-J ≤ 20) and 14.0 patients (those with baseline SIB-L-J > 20).
This pooled analysis also examined the subscales of the SIB-J, finding that memantine was associated with less worsening of language ability, visuospatial cognition, attention and praxis compared with placebo, again similar to the results of studies conducted overseas [1,2,22].
34, 35 Consistent with these findings, a recent post hoc analysis reported that, after 6 months' treatment with donepezil 10 mg/day, patients with moderate to severe AD showed less worsening in language compared with those receiving placebo.
And for nearly a decade, members — citing concerns about worsening drug abuse — inserted language into the city's budget bill that prohibited financing needle exchange programs.
Despite the evidences, the correlation of language deficits, worsening academic performance, and auditory processing in BECTS has not been totally explored.
Language variant AD is often an early-onset AD (EOAD) syndrome of gradually worsening non-fluent speech typified by significant agrammatism, phonemic paraphasias, relative preservation of memory, and often atrophy of the left perisylvian region on imaging [ 27- 29].
A number of reports, including one last October by the U.S.-China Economic and Security Review Commission, of which Mr. Wortzel is vice chairman, have used strong language about the worsening threat of computer attacks, particularly from China.
