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The negative correlations support that deteriorating health was correlated with worsening function (higher scores on the SFI-Sp).
An excessively high inflammatory response as expressed by overproduction of CRP may lead to worsening function and remodeling of the left ventricle [ 4, 5].
The triangle of increasing radiological damage, worsening function with longer disease duration has been described by many others, varying from stable progression rate [ 17] to a steeper worsening, but earlier plateau [ 18].
The directional trend however supports the construct validity and the determination of the LLFI-Sp as appropriate in terms of face and content validity as a deteriorating health correlates to worsening function.
But here in our current study, the type 2 diabetes patients with a higher HbA1C, fasting glucose and a longer duration of diabetes are likely to be accompanied by worsening function of beta cells to secrete adequate amounts of insulin.
In the original PHQ-15 validation study, which comprised of 6,000 unselected primary care patients, higher PHQ-15 scores were also strongly associated with worsening function on all six SF-20 scales - a longer version of the SF-12 used in the present study -, as well as increased disability days and health care utilization [ 7, 17].
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Non-Adherent participants showed worsening functioning over time, while PAP Users showed stable or improved functioning, similar to controls.
26, 27 Thus, a claim of a causal link between exenatide use and worsening kidney function remains unsupported.
Thus, to date, a claim of a causal link between exenatide use and worsening kidney function remains unsupported.
Correlation between AM particulate load (AMPL) and worsening lung function supports a possible pathophysiological role [ 13].
Several reports revealed that the use of a high dose of diuretics was a prognostic factor of worsening renal function and prognosis of ADHF patients [ 7, 17, 20], and inhibiting worsening renal function is an important issue for ADHF patients.
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