Such membranes have been shown to arise from corneoscleral stromal downgrowth [[4]], but the potential effect of silicone oil in accelerating or worsening the development of a retroprosthetic membrane must be considered.
This finding suggests that the early effects of bereavement are not primarily mediated through worsening or development of chronic disease.
The modification indices suggested an additional direct effect of "care dependency" and "worsening disease development" on HRQoL.
However, growing clinical and experimental evidence indicates that CaC crystals may induce real microcrystal stress on synoviocytes and chondrocytes, leading to OA lesion worsening and/or development [ 5].
Definition criteria include IPF diagnosis, unexplained worsening or development of dyspnea within 30 days, new lung infiltrates (mainly ground glass upon honeycomb), and exclusion of any identifiable or treatable cause of lung injury [ 6].
Among these admissions we further separated the ones representing IPF-AE according to the IPF Clinical Research Networks Investigators consensus (IPF diagnosis, unexplained worsening or development of dyspnea within 30 days, new lung infiltrates (mainly ground glass upon honeycomb), and exclusion of any identifiable or treatable cause of lung injury) [ 2].
This 2-year prospective, longitudinal study of patients with diabetes type 2 and mild NPDR (ETDRS levels 20 and 35 at baseline) shows that MA turnover in field-2 is a good indicator of retinopathy worsening and development of CSME needing photocoagulation.
The lens cells in the anterior chamber also worsen the development of the anterior segment and can delay eye development in general.
Cardiac edema was regularly observed in embryos from all classes and worsened as development proceeded; class II and III embryos did not survive past 7 days.
For example, mice with inactivation of perlecan, an ECM protein required for collagen fibril assembly, fail to organize cartilage growth plates after the mesenchymal condensation stage and the phenotype progressively worsens as development progresses.
