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Furthermore, we dichotomized the GPE scores into "improved" ("completely recovered" and "much improved") versus "not improved" ("slightly improved", "not changed", "slightly worsened", "much worsened", "worse than ever"), and added a question about treatment satisfaction (also on a seven-point scale).
Global rating of change will be measured using a 7-point Likert scale, with participants rating their overall change since the baseline assessment as "completely recovered", "much improved", "slightly improved", "no change", "slightly worsened", "much worsened", or "vastly worsened" [ 78, 79].
Richard A. Moscicki, chief medical officer for Genzyme, discounted the ability of the patients in the trial to remain off Cerezyme, saying they apparently had mild disease that would not have worsened much even if they had taken no drugs at all for six months.
Improved implies completely recovered and much improved, whereas not recovered implies slightly improved, not changed, slightly worsened, much worsened, and worse than ever [ 31].
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PEM 19 was assessed with the following question: does physical activity influence fatigue; improving, no effect, some worsening, much worsening?
In this study, patients' own classification was rated on a 4-point scale ("completely recovered", "improved", "unchanged" or "worsened"), [ 30] while other studies have used 5 or 7-point scales to that end, in which "improvement" and "worsening" were split into further categories, such as "much improved", "slightly improved", "slightly worsened" or "much worse" [ 1- 8, 11].
Patient global assessments of overall treatment outcomes will be measured by a single item consisting of a five-point Likert-scale question (much improved, somewhat improved, the same as baseline, somewhat worsened or much worsened) to assess the immediate and short-term treatment outcomes in all three conditions.
The currents had worsened — too much even for the boats.
The flooding was greatly worsened because much of the storm-washed region was already sodden from record August rains.
It came at a time when relations between the United States and Russia, which have worsened throughout much of the Obama administration, have been especially jolted by accusations of Russian hacking and subterfuge in American politics.
Today, Greece's problems have worsened so much that they threaten to rip apart the euro and the decade-old 17- country monetary union created within the European Union to manage the prized common currency.
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