"Socially and morally it cannot be right that we are allowing children to worsen in terms of condition," Ms Longworth told the Health Select Committee.
In their series of paediatric crosslinking, Caporossi et al. report worsening in terms of topographic and pachymetic data in 4.6% of eyes; however the term "worsening" is not defined [ 16].
In a preliminary analysis of responsiveness, changes in EAPIQ scores between baseline (week 0) and follow up (7 10 days after baseline) were compared among groups of patients who rated themselves as 'better', 'stable' or 'worsened' in terms of 'eye allergies', 'all allergies', and 'overall health' (as assessed using the Health Change Questionnaire).
At baseline, participants reported significantly reduced QOL compared with the general population, while QOL had worsened significantly longitudinally in terms of physical function and bodily pain.
This worsening was different in terms of outcomes according to the patient.
In this study, we found that the treatment with SGA may worsen metabolic profile in terms of decreasing vitamin B12 and folate levels and increasing Hcy levels.
The case reported is peculiar, as it focuses on an extremely rare condition which, if ignored, leads to a delayed treatment, thus worsening the prognosis in terms of survival.
That reputation worsened in the two terms of Mr. Bellone's predecessor, Steve Levy, who became nationally known for his harsh tone and hard line on illegal immigration.
Model predictions revealed the occurrence of operating surface temperatures up to 1100 °C and allowed to quantify the progressive worsening of reactor performances in terms of a loss of reforming activity localized in correspondence of the catalyst hot spot.
The results obtained from the case-study analysed clearly demonstrate that climate change combined with increasing urbanisation is likely to lead to worsening river water quality in terms of both frequency and magnitude of breaching threshold dissolved oxygen and ammonium concentrations.
