On the other hand, less patients in the sodium hyaluronate group compared with the placebo group were considered "slightly worsened" or "gravely worsened" at Week 25 by both patient's judgment (6 versus 15 patients, respectively) and investigator's judgment (7 versus 14 patients, respectively).
It worsened at Wimbledon as he advanced to the semifinals.
The situation worsened at the centre as the day went on.
Relations with China worsened at first but improved in 1984 with an exchange of state visits.
Last week, an already pressing financial crisis worsened at Excite@Home, which offers broadband service and operates the Excite portal.
That practice often understates bad loans, which have worsened at many banks, leading to a second round of losses.
No 10 initially claimed Rajoy had promised to ensure the delays would be eased but queues instead worsened, at one point reaching four hours in the summer heat.
Analysts, with first quarter figures out on 11 May, took the news as a sign that trading had worsened at the electricals retailer.
Arlene's daughter's condition worsened at she got older, manifesting as tantrums and then a compulsion to lick -- the garage floor, electrical outlets, a gym mat at school.
Some American officers say it is no coincidence that the problems have worsened at a critical juncture for the Awakening movement and for American forces.
As the day progressed, the storm worsened; at its peak, winds reached 70 75 knots and waves swelled to heights of 25 feet (8 metres).
