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At the BRCA1/2 test result disclosure, both women who received a NU or a UV result were similarly warned that possible development in genetics could explain women's family history of cancer in the future and so it seems that evocation of a 'mutation' convey a worrisome connotation.
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The term self-mutilation is also sometimes used, although this phrase evokes connotations that some find worrisome, inaccurate, or offensive.
I certainly have no plans to go on to pears, apples or oranges". Most worrisome to him are the lewd connotations certain buyers could exploit.
But it is worrisome.
And that's worrisome".
Sochi is more worrisome.
This is worrisome.
"The connotation, mainly, is crime".
And I find that worrisome, really worrisome.
"Basement has an ugly connotation".
The proper connotation is Joe Sixpack.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com