A number of preclinical and clinical trials of MSCs are currently in progress worldwide; however, protocols for the use of MSCs, including optimized culture conditions, have not been standardized [ 7, 12].
As a consequence of this trial, tranexamic acid has been incorporated into trauma treatment protocols worldwide.
Mercaptopurine (6-MP) is a highly effective chemotherapeutic agent for the treatment of childhood acute lymphoblastic leukemia (ALL), and is extensively used in therapeutic protocols worldwide [ 1].
The thiopurine antimetabolites mercaptopurine (MP) and thioguanine are analogues of the purine bases hypoxanthine and guanine and these medications are a major component of paediatric acute lymphoblastic leukaemia (ALL) treatment protocols worldwide.
In the nearshore, for example, the NaGISA project has focused on the benthic diversity associated with rocky shores and on seagrass communities by using a common protocol worldwide.
The main challenges that remain are the under recognition and underestimation of the morbidity of such complications as well as the absence of affordable worldwide-established treatment protocols.
While the interRAI suite of instruments -and more specifically the interRAI PC instrument- is tested and implemented worldwide, this study protocol can provide guidelines to evaluate the effect, the validity and the usability of interRAI PC in other countries.
To the best of our knowledge, this is the first systematic review to compare the worldwide variability in practices, protocols, and transplant outcomes for uDCD in order to inform future protocol development and health policy.
Despite the rising need to validate new diagnostic biomarkers that may help to diagnose vulnerable atherosclerotic plaque, so far, due to the variability of PET imaging protocols used worldwide, measurements obtained through different studies could not have been compared [19].
Over 30 patients have been treated worldwide using the current protocols, and recent trials provided the demonstration of long-term clinical efficacy of HSC gene therapy for SCID-ADA in combination with gene and cell therapy.
