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Worldwide frequency patterns of J1-M267, J2b-M102, J2b-M102, J2b1-M205 and J2b2-M241 indicatheirheir unique history of distribution (Figs 1 and 2).
Using the Immune Epitope Database Analysis Resource, cytotoxic T lymphocyte (CTL) epitopes of the HPV-16 E6 and E7 proteins were predicted according to worldwide frequency distributions of HLA-A alleles HLA-A*01 01 HLA-A*01 01 -A*02 01, -A*02 06, -A*03 01, -A*11 01, -A*24 02, -A*31:01 and -A*31 01).
In summary, we have demonstrated that the worldwide frequency distribution of 370A is highly unusual and that 370A was likely rising in frequency by positive selection in East Asia prior to 10,000 years ago.
Figure 1 demonstrates that 370A has a highly unusual worldwide frequency distribution, supporting a scenario in which the 370A allele was driven to high frequency in East Asians and Native Americans by positive selection (Figure 1).
This widespread mutation appears to have the highest worldwide frequency in Lebanon.
The worldwide frequency of interstitial lung disease to date in ~92,750 patients who have received gefitinib is <1.0% [ 18].
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Both B57 and B58 have lower worldwide frequencies than B51 and B35; therefore, the statistical power to detect associations with the same ORs is worse.
We have previously developed the Allele Frequency Net Database (AFND, http://www.allelefrequencies.net), which captures worldwide frequencies of alleles, genes and haplotypes for several immune genes, including KIR genes, in healthy populations, covering >4 million individuals.
These results, based on sequence-based neutrality tests, LD-based tests and inter-species comparisons, therefore suggest that the high worldwide frequencies of MBL2 deficiency alleles result from a relaxation of the selective constraints on the human lineage.
The distribution frequency of HPA varies among populations worldwide.
The worldwide allele frequency distribution of SNP shows not only a high-derived allele frequency in Asians, but also in Americans, which is suggestive of functional adaptation.
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