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These 7 promiscuous epitopes from NP, RdRp and GP were found to have world-wide population coverage of more than 95% indicating their potential significance as useful candidates for vaccine design.
According to the Toba catastrophe theory, it had global consequences for human populations: it killed most humans living at that time and is believed to have created a population bottleneck in central east Africa and India, which affects the genetic make up of the human world-wide population to the present.
Epstein-Barr virus (EBV) is a common human gamma-Herpesvirus infecting more than 90% of the world-wide population.
To further investigate potential scale effects, we applied POPS to 77 world-wide population samples from the HGDP data set excluding two language isolates (Basque and Burushaski) and grouping the sub-Saharian samples in a reference cluster (Table S2).
Gastrointestinal (GI) symptoms, common in the world-wide population, create not only higher health care utilization, but also negatively impact daily activities and quality of life [ 6- 8].
Nineteen world-wide populations (497 individuals) and ten East Asian (EA) populations (192 individuals) were included in the metadata.
To further investigate the evolutionary processes in the sphinx promoter region, we performed a polymorphism survey among world-wide populations.
We inferred individual ancestry proportions with the frappe program [44] for 30 individuals of our Tibetan population, 497 individuals of 19 world-wide populations, and 167 individuals of 8 EA populations.
Numbers of iterations in the burn-in period and MCMC replication were 4,000 and 6,000, respectively, for the runs of world-wide populations, and both 10,000 for runs of sub-regions.
We report here that the most common variant associated with PD in several world-wide populations, the p.G2019S mutation in LRRK2, is not overrepresented in this Nigerian population of PD patients; similarly, sequence variants in PRKN, which represent a significant proportion of PRKN mutations underlying PD, are also not significantly present in the studied cohort.
Particularly, an unprecedented deep-resequencing project launched in 2008, the 1000 Genomes Project (http://www.1000genomes.org/), ambitiously aims to provide a most detailed map of human genetic variation through genotyping at least 1000 human genomes from world-wide populations using the next-generation sequencing technologies [27], [28].
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