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In previous works, compounds (2) and (3) have shown to be less active than hyperforin in vitro as inhibitors of synaptosomal serotonin reuptake, but they had a comparable effect as growth inhibitors of P. falciparum cultures, although showing less toxicity [17], [22].
In these works, compounds including 2- 4-N,N-dimethylamino) phenylimidazo [4,5-b]pyridine (DMAPIP-b) [ 10], imidazolium chloride ionic liquids [ 11], prednisolone [ 12- 4-N,N-dimethylaminoveratrol [ 14], genistein [ 14], curcumin [ 14– 16], malachite Green [ 17], bright red 6C [ 18], anticancer drugs [ 19], heparin [ 2- 4-N,N-dimethylamino [ 2- 4-N,N-dimethylamino
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Through the course of this work, compounds were identified that inhibited the proliferation of LNCaP cells stimulated by AED in vitro.
Tsu, unpublished work), compounds were optimized for in vitro β5 potency against human 20S, whereas crystal structures of representative examples were determined with the yeast 20S open-gate mutant in order to guide further library design.
"But after reviewing the facts, we were compelled to publish the article as soon as possible to set the record straight and stem the tide of future work compounding the error".
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