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In general, it requires several transcription factors working in combination to activate a gene.
This requires a number of different instruments, including satellites, radars, optical imagers, and ground-based magnetic measurements, working in combination to observe different aspects of the coupled system and provide the input data for the development of sophisticated modelling and forecasting techniques.
In reality it's probably going to take more than one drug working in combination to actually cure them.
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The invasions and the civil wars worked in combination to disrupt and weaken the empire over a span of half a century.
We see a place for all of these materials, especially when they work in combination to provide decent livelihoods for communities and significantly reduce the impact on the environment.
These factors appear to consistently work in combination to '…influence who enters and stays in the workforce, as well as the quality and effectiveness of their services for children and families' (IofM and NRC 2012, 61).
We suggest that Rfx3/Foxj1 may work in combination to regulate directly a subset of ciliary targets in the way we have identified for Rfx/fd3F.
Homeostatic potentiation and depression are independent processes with distinct mechanisms, and which work in combination to allow fine-grained control of communication across synapses.
We suggest that in characterizing the skeletal muscle transcriptome, one might expect that different signal systems may work in combination to shift the disease stage of pancreatic cancer patients towards cachectic conditions.
While we have demonstrated that age structure, mating behavior and fitness costs could work in combination to affect the population dynamics of gene-drive, we lack detailed field studies in these aspects.
Regulatory mechanisms mentioned above may work in combination to produce a variety of expression profiles, where even in bimodal genes one mechanism may account for expression level changes within a single mode of expression and an alternative regulatory mechanism may account for expression level changes between modes of expression.
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