Sentence examples for work upstream of from inspiring English sources

We next investigated the possible involvement of Notch pathway in order to identify the mechanism at work upstream of NGN3.

Further studies will explore whether American ginseng extract can work upstream of the colon, in peripheral blood cells or lymphoid tissues.

By blocking signaling through the LTα pathway, as well as by depleting LTα-expressing cells, which are dominant sources of TNF-α and IL-6, pateclizumabis likely to work upstream of TNF-α blockade.

Applying a chemical that stimulates cell division to the skin of the mice triggered more bursts of ERK activity; whereas fewer bursts were observed if Hiratsuka et al. used other chemicals to block the activity of some of the signaling proteins that work upstream of ERK.

These data suggest that CXCL12 inversely governs Mcl-1 and Bcl-2 through the Bim regulator and that Bim knockdown does not modulate the ability of those cells to adhere suggesting focal adhesion signaling is working upstream of Bim.

Our in vitro data suggested that Ndel1 works upstream of or at least serially with neuronal Vimentin in the regenerative pathway as co-silencing of Ndel1 and Vimentin does not further impede outgrowth of lesion-conditioned DRG neurons when compared to neurons treated with Ndel1 siRNA (Fig. 5).

In addition, MdCIbHLH1 was found to upregulate the expression of MdCBF1, MdCBF2, MdCBF3, MdCBF4 and MdCBF5, further confirming that MdCIbHLH1 works upstream of the MdCBFs.

It seems that Shh might have a role in the spatial temporal production of angiogenic growth factors during embryonic and postnatal angiogenesis, working upstream of vegf, which in turn operates upstream of Notch.

However, while ROS have been implicated in the activation of MAPKs [ 34], we show here that this early activation of p38MAPK during reperfusion actually works upstream of changes in cellular ROS levels.

It is possible that CD28 blockade works upstream of these effector cells and that the disease activity in RA is dependent on the continuous recruitment of naïve and central memory cells into the effector cell pool.

Bethke et al. [ 57] showed that NO works upstream of GA in a signaling pathway, supporting our results that GA is possibly linked to higher NO levels in WT.