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He won nomination despite opposition from Ronald Reagan, Senator John Warner, and other traditional Republicans.
Blaine finally won nomination for the presidency in 1884, only to lose by an extremely narrow margin to the Democratic candidate, Grover Cleveland, after an especially virulent campaign.
At the Republican convention in 1952, Nixon won nomination as vice president on a ticket with Dwight D. Eisenhower, largely because of his anticommunist credentials but also because Republicans thought he could draw valuable support in the West.
But a read of the electoral tea-leaves makes one thing clear: it is very difficult to unseat an incumbent.In Montana, for example, Conrad Burns, a Republican senator, won nomination for a fourth term despite close ties to Jack Abramoff, a corrupt and now disgraced lobbyist.
Jeb at least three times declined to answer whether he'd support Trump if he won nomination.
He became such a powerful political figure that he repeatedly won nomination by Democratic, Republican and Progressive parties, regardless of which was dominant in his State of the nation.
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Thanks to Wyoming, a record 14 women have now won nominations for governor.
Barring a disastrous loss this November, no insurgent is likely to win nomination without that combination.
For all that, friends of Ms. Rice said she believed she could win nomination and be a successful secretary of state.
After an unsuccessful attempt to win nomination for president in 1808 he was reelected vice president under Madison.
It's hard to win debates — and to win nominations — unless you make an effort to do that.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com