Also, higher expression of myogenin and VEGF were seen in the MDSC group at both 4 and 8 wk time points.
H-2Kb is low in GFP-marked NPC surviving at the 2 wk time point and the intensity of staining is not obviously different in C57B/6 NPCs surviving in the isograft or allograft contexts.
In recipient mice that were seeded with control, immunosuppressed but untreated mice (Not Tx 2, 4, 6), no cyst forms were detected after 2 wk time of immunosuppression; but log10 mean cyst counts per lung of approximately 5.0 and 6.0 were detected in the 4 and 6 wk groups (Fig. 8a, blue, green bars).
By Reverse Transcriptase qPCR analysis (which also served as a viability assessment), an average of approximately 1, 48, and 1000 nuclei per rx (reaction) were detected in groups of mice at the 2, 4, and 6 wk time points in mice infected with treated P. murina (Fig. 9b, Anid Tx 2, Anid Tx 4, Anid Tx 6).
These analyses also included the 5 wk time period in both groups (3 dogs/age/group).
Yet at the 16 wk time point, 173 (118 up-/55 down-regulated) miRNAs were DE in xlpra2 compared to normals (Additional file 3).
In contrast, there were limited expression differences between the 16 and 7 wk time points (1 up-/1 down-regulated) (Additional file 1).
In mutant retinas, the 3 wk time point (induction phase) is prior to the beginning of apoptosis and retinal structure is normal.
In contrast to the 10 wk time point, the data at 24 wks demonstrated a similar pattern of expression in superior and inferior retinas indicating a region-independent involvement of apoptomirs at this later age.
Mean apoptotic index in C57BL/6 mice was increased following infection at the 6-wk time point in both males and females and remained elevated 48 wk following infection in females, but returned to baseline amounts in males.
