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Figure 4, Presents Bland-Altman plots of log C2 baseline and 2 wk difference scores for both the KoKo DigiDoser and Mefar dosimeter.
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Compared to Vela, Imig (60 U/kg/wk) had lesser effects at reducing hepatic GC (p = 0.0199) by 4 wks; this difference disappeared by 8 wks when nearly WT levels were achieved by Imig.
At 12 wk, no differences in BHBA concentrations were observed among treatments.
By 8 wks, this difference disappeared as WT GC levels were achieved with either GCase.
Thus, expression changes in rcd1 were similar to those in xlpra2, although in the latter disease they appeared to be slightly delayed (i.e. between 16 7 wks); these differences reflect the more severe and faster disease course of rcd1.
At a histological level, when administered to either 5-wk or 20-wk mice, a difference in the quantitative liver (p = 0.28 0.84) or lung (data not shown) cytopathies was not observed when comparing the effects of either GCase.
After 2 wk no significant difference was observed for FR and FS plants, 64 g H2O·g FDW-1 and 58 g H2O·g FDW-1, respectively.
Figure 6E and F depicts the relative variable fluorescence between Fo and F300 μs (WK) and the differences of normalized N-treated transients minus 6000 μM N-treated transient (ΔWK).
By 4 wk, clear phenotypic differences were evident between the double transgenic animals and their control littermates, including a significant decrease in body mass and visible kyphosis (Fig. 2C, 2D).
Parental mouse strains C57BL/6J and A/J fed a HFHC diet for 8 wk elicited significant differences in the hepatic gene expression of Xbp1s: 1.0 ± 0.2 vs. 0.4 ± 0.2 in A/J and C57BL/6J mice, respectively (P < 0.05).
Fig. 6C and 6F depicts the relative variable fluorescence between Fo and F300 μs (WK) and the differences of normalized P-treated transients minus 1000 μM P-treated transient (ΔWK).
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