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HHEX SNP rs1111875 showed a trend towards an association with insulin secretion that however did not withstand adjustment (unadjusted p = 0.09, adjusted p = 0.16, dominant model).
Similarly, association of BMPR2 SNPs with quantitative traits was moderate and would not withstand adjustment for multiple testing (e.g. Bonferroni correction).
Although this combination did not show any significant association in the overall group comparisons, stratification according to NVP dose showed a trend (P = 0.06; OR = 4.46) of high representation in INF infants compared to EU infants in the group whose mothers received a single dose NVP (Table 3), however this did not withstand adjustment for MVL (Table 2).
Suggested differences in education and function did not withstand adjustment for multiple testing.
However, their significance did not withstand adjustment for multiple testing using the Bonferroni correction.
We identified significant correlations of NAMPT with systolic blood pressure and endothelial function that did, however, not withstand adjustment for BMI SDS in partial correlation analyses (Table 1).
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