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Domesticated wild hybridization can also provide insights into plasticity as a mechanism for evolutionary change, albeit indirectly and without uncoupling it from natural selection.
Similar to other tissues, mammalian liver mitochondria contain little cholesterol relative to phospholipid, so we predicted that brief incubation with saponin would disrupt plasma membranes without uncoupling mitochondrial oxidative phosphorylation.
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Additionally, exposure to cold will stimulate heat production in mitochondria [16] by causing protons to pass through the inner membrane without ATP production, which is facilitated by activation of specific uncoupling proteins (uncoupling protein 1 or UCP1).
Binding of substrate analogue l-lysine causes oxidation of the NADPH cofactor, without subsequent production of hydroxylysine, effectively uncoupling the reaction.
By contrast, depletion of DKC1 in MEFs blocked the reactivation of epithelial genes (Ecad and Epcam) without significantly perturbing the silencing of mesenchymal genes, thus effectively uncoupling the otherwise tightly coordinated MET induced by OKSM (Liu et al., 2013).
Here, we found that in M2 macrophages P2X7R activation induces only a weak ROS response that may be owing to a specific uncoupling from recruitment of the NADPH oxidase complex without alterations in P2X7R up-stream signalling, correlating with the low level of NLRP3 activation and IL-1β release found in intermediate polarized macrophages after ATP/P2X7R stimulation.
Name: Conscious uncoupling.
"Feel it," she urged, uncoupling the magnet.
Indeed, there's a strong argument for uncoupling the music from the apps entirely.
That's what Harari means by the "uncoupling" of intelligence and consciousness.
"After a period of denial, we've chosen conscious uncoupling.
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