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A therapeutic strategy using TUDCA may eventually lead to effective treatment of SCI without toxic effects in humans.
Moreover, in infected mice, this peptide was also effective in reducing parasitemia and increasing survival without toxic effects.
Recently, we reported that PL is remarkably effective in inhibiting the growth of various prostate cancer cell lines without toxic effects on normal prostate epithelial cells [7].
However, efficacy is limited by our inability to deliver sufficient active metabolite into cancer cells without toxic effects on normal tissues.
But when mouse peritoneal macrophage-like cells were treated with SWCNTs in the range 0 7.3 µg/mL for 4, 8, 12 and 18 h, the cells ingested the nanoparticles without toxic effects [148].
CCD and EDTA were tested at different concentrations to establish working concentrations for maximum inhibition without toxic effects on cells.
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No anthelmintic, however, is completely effective, completely without toxic effect upon the host, or equally active against all worms.
In vivo, the CPT-11 metronomic schedule is effective against tumour and microvessel growth without toxic effect on mice.
All peptides tested were used in a concentration (250 μg/mL) previously demonstrated in literature as effective to induce biologic effects (32), but without toxic effect on the viability of macrophages after 3 h of exposure.
Interestingly an amelioration of liver architecture was noted at 125 pg/mL without toxic effect.
Also, a reduction of 75% was observed in HEL cells at a concentration of 75 μg/mL without toxic effect.
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CEO of Professional Science Editing for Scientists @ prosciediting.com