Sentence examples for without the mediator from inspiring English sources

However, a mediator cannot enforce behavior; that is, agents can play in the game directly, without the mediator's help.

A similar band was detected without the mediator (Fig. 10B, lane 2), but it often disappeared if the mixture was incubated for a longer time before the electrophoresis (An example is shown in Fig. 10C, lane 2).

Each generated dataset was fit with the SEM, the LMM1 (i.e. with the mediator as a covariate), and the LMM2 (i.e. without the mediator as a covariate).

We also assessed whether FMD and/or obesity were potential mediators in the relationship between days of insufficient sleep and each chronic disease by measuring the percentage change in effect between a model with and without the specific proposed mediator = [(OR model without the mediator- OR model with the mediator)/ (OR model without the mediator - 1)] * 100 [ 28, 29].

In short, models are fitted for the outcome both with and without the mediator, and the difference in the coefficients for the exposure is taken as a measure of the indirect or mediated effect.

The traditional way of unraveling direct and indirect effects, by comparing exposure effects in regression models with and without the mediator, will often produce flawed results, among others due to confounding from time-dependent covariates [ 39].

Total effect (relationship between each exposure and outcome, with and without influence of the mediator), direct effect (relationship between each exposure and outcome without influence of the mediator), indirect effect (relationship between each exposure and outcome with influence of the mediator – captured by the mediator).

Estimation of this indirect effect is straightforward in a linear regression model: the difference in the coefficients for the legal-status variables in models with (the "reduced model") and without (the "full model") the mediator variable can be considered the indirect effect of that variable.

The cell layers were then rinsed with serum-free DMEM followed by the addition of DMEM with or without the inflammatory mediator TNFα (20 ng/ml, according to previous dose-response studies [ 19, 30]) and in the absence or presence of the inhibitors SP600125 (SP; Sigma-Aldrich, St . Louis MO, USA), Bay 11-7082 (Bay, Sigma-Aldrich) or Ro 106-9920 (Ro, Tocris Bioscience, Bristol, UK).

Specifically, the natural direct effect is the effect one would observe if the exposure could be changed without inducing a change in the mediator.

Further studies are required to prove that HSP20 phosphorylation is the mediator of relaxation without MRLC dephosphorylation.