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The phrase "without significantly affecting" is correct and usable in written English.
You can use it in situations where you are describing something that is being done without causing a significant change in the existing situation. For example: "He was able to finish his project without significantly affecting other projects at the company."
Exact(59)
By using the acoustic port, the group found that the driver could be placed at any of a dozen points behind the L.C.D. screen without significantly affecting the sound the panel ultimately produced.
Thus, the source can choose between the two schemes without significantly affecting medium access control.
As expected, the thermal stability is even further enhanced, without significantly affecting the resistivity.
Equally important, such behaviour is gained without significantly affecting the workability of the mixture.
ADS can suppress Cu dissolution without significantly affecting the surface chemistry of Ta.
Soluble Aβ1-42 also increased the amplitude of INaP without significantly affecting its activation properties.
The results demonstrate that eIF4E2 mainly represses reporter expression on the translational level, without significantly affecting the encoding mRNA levels.
The result showed that β-glucosidase might be inhibited by glucose in the medium without significantly affecting polysaccharide flocculant activity.
The broader the aperture distribution is, the more fractures can be eliminated without significantly affecting the overall flow behavior.
In the latter group, these policies have reduced the hazard into permanent retirement without significantly affecting gradual retirement.
In general, MNs can improve the throughput for the VUEs without significantly affecting the performance of outdoor UEs.
More suggestions(15)
without significantly undermining
without significantly deteriorating
without significantly interfering
without noticeably affecting
without significantly jeopardizing
without significantly effecting
without significantly impacting
without dramatically affecting
without considerably affecting
without drastically affecting
without greatly affecting
without significantly impairing
without significantly decreasing
without significantly damaging
without significantly increasing
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com