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To compare proteomic profiles of seminal plasma from adolescents with varicocele and changes in semen quality with the plasma from adolescents with varicocele without seminal changes and from adolescents without varicocele.
PATIENTS AND METHODS: We retrospectively analysed 485 men in the DPC cohort with PSM and/or ECE but without seminal vesicle or lymph node involvement.
Aneuploidy was noted in 40 of 59 specimens (68 per cent) exhibiting seminal vesicle involvement, compared to 11 of 29 (38 per cent) without seminal vesicle involvement (p less than 0.01).
OBJECTIVES: To validate the Shared Equal Access Regional Cancer Hospital (SEARCH) nomogram to better risk stratify men with intermediate-risk pathology after prostatectomy (positive surgical margins, PSM, and/or extracapsular disease, ECE, without seminal vesicle or lymph node involvement) in a tertiary referral centre (the Duke Prostate Center, DPC).
Clinical target volumes (CTV) included the prostate, with or without seminal vesicles.
For insemination with spermatozoa without seminal plasma, spermatozoa were isolated from SP using the single layer centrifugation technique, SLC [ 22, 23].
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After fixation, the specimens were weighed with and without the seminal vesicles.
In the pathology institute the prostate volume (Prostatvolumen) was calculated after formalin fixation by weighing the prostate specimen without the seminal vesicles.
Initially viewed as "junk" DNA without function, seminal studies in rodents [ 15, 16] and primates [ 17- 19] indicate a far more important role for SINEs in genome organization, gene evolution, and disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com