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Patients without renal involvement have the 'limited' form of the disease [4,7-10] [4,7-10]
6 Rarely, LCDD occurs without renal involvement.
Patients with biopsy proven lupus nephritis were compared to patients without renal involvement.
Patients without renal involvement (n = 13) had increased levels of HMGB1 compared with HC (P = 0.023).
Serum HMGB1 levels were higher in patients with renal involvement compared to patients without renal involvement.
Previously studies have reported no significant difference in HRQoL between SLE patients with and without renal involvement [ 9].
Similar(39)
Total T cell subtype counts were also measured in additional urine samples from 43 SLE patients without acute renal involvement.
The patient was diagnosed with GPA without significant renal involvement and was started on daily prednisone (0.5 mg/kg/day) and weekly methotrexate (15 mg/m/week).
In SLE patients without active renal involvement only low numbers of T cells were detected (median 29 CD4+ and 25 CD8+ T cells/dl urine, n = 55).
We also compared pSLE patients with biopsy-confirmed class III or IV proliferative nephritis (n = 23) and without significant renal involvement (n = 18).
Efficacy and tolerability when added to standard therapy, but without a steroid-sparing effect, have recently been demonstrated in two phase III clinical trials in patients with SLE, without significant renal involvement.
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