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Interestingly, sc-tPA is proteolytically active even without proteolytic processing.
Previously, the main concern has been the risk of false negative results as a consequence of using only caspase fragmentation as marker of activity, based on the observation that, for example,, caspase-9 can be activated without proteolytic processing.
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As APP proteolytic processing is a sequential process, the repression of any individual secretase would inhibit release of the AICD.
NEXT is a membrane-bound, γ-secretase-dependent, constitutively active form of Notch that can function without ligand but still requires intracellular proteolytic processing and trafficking [ 52].
Proteolytic processing of β-CTF released Aβ.
Proteolytic processing of viral polyproteins is essential for retrovirus infectivity.
Proteolytic processing of the coronavirus replicase polyproteins is essential for ongoing viral ribonucleic acid (RNA) synthesis.
The 3C protease (3CP) does the majority of the proteolytic processing.
This ligation of exteins differentiates protein splicing from other forms of proteolytic processing.
However, alternative APP proteolytic processing produces a complex roster of Aβ species.
Our studies characterized the proteolytic processing of Vip3Aa and provided new insight into the activation of this novel Bt toxin.
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