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The study will also include 500 70-year-olds without plaques, for comparison.
This idea is supported by a study published in April in the Annals of Neurology, which showed that mice without plaques, but with floating beta-amyloid, were just as weakened by the disease as mice with both.
The new mice, described in tomorrow's issue of Nature, also show neuron and memory loss without plaques, suggesting that they might provide a testing ground for drugs designed to slow the progression of the disease in humans.
They're all unmarked, too, without plaques or memorials explaining who settled where, or why they were drawn to isolated swaths of salt bush.
After the visit there appeared 20 motorcycles without plaques, cell phones which allowed for the state to maintain surveillance on the population, more police and military personnel, three new police cars, and three new judges.
In Table 3, SLE-patients with or without plaques are compared.
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Without plaque, a person with memory loss did not have the disease.
IMT was recorded 1 cm before the carotid bulb in a part without plaque on the left and right side.
For carotid plaque, logistic regression analysis was used to evaluate the difference of genotype distribution between with and without plaque group.
Importantly, this accumulation, without plaque formation, in contrast to the plaques observed in the human APP-overexpressing mice, did not hinder better learning abilities in aged NEP-deficient mice.
Since already the accumulation of soluble forms of Aβ (monomeric and oligomeric) without plaque or fibril formation is assumed to induce neuronal pathology and consequently learning and memory deficits [12], [19], [20], we tested learning and memory performance in NEP knockout mice in comparison to wild-type animals.
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