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Other artists, such as Konrad von Soest, who executed the "Niederwildungen Altar" about 1403, seem to have reflected developments elsewhere without pioneering anything strikingly new.
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What is certain, however, is that without pioneer patients such as Washkansky, extreme medicine cannot develop into common or garden everyday lifesaving.
Without much fanfare, a pioneering band of schools are slowly eroding a barrier between state and private education that Mr Seldon calls "the biggest wasted opportunity in Britain".
This company is producing technologically advanced prosthetics and exoskeletons, pioneering bionic technology for people with or without a disability.
It was pioneering work.
Jim loved pioneering entrepreneurs.
Helen Brush Jenkins, 94, pioneering photojournalist.
But, if Netflix pioneered programmes without a TV set, it was sometimes tempting to suggest that the conventional networks had TV sets without the programmes.
Without the storytelling techniques pioneered over the last sixty plus years by daytime serials, these modern-day shows would have lacked the blueprint for creating entertainment franchises of enduring popularity.
Without his pioneering contributions, Al Nasir believes hip-hop wouldn't have evolved beyond good-time party music.
They are also highly unlikely ever to have existed without the pioneering musical efforts of tonight's legendarily idiosyncratic headliner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com