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The Technical Appendix contains the equations defining each input (e.g., total adverse outcomes without PEP) of this equation.
Mumps attack rates were 0% among third-dose recipients versus 5.2% among 2-dose recipients without PEP (p = 0.57).
To calculate adverse outcomes with and without PEP, we constructed a decision tree for each target group illustrating all possible outcomes after exposure to C. burnetii.
Of particular importance is the probability of severe cases of illness without PEP use; 13% of the general population, 36% of the high-risk population, and 46% of pregnant women would experience severe illness.
The probabilities associated with each possible event were multiplied and applied to a population of 100,000 to estimate the number of people who would experience a given outcome with and without PEP.
Total medical outcomes averted for each group were calculated by using the following general equation: Total medical cases averted = (Total adverse health outcomes caused by Q fever without PEP) – (total adverse health outcomes caused by Q fever remaining after intervention) – (cases of PEP-related adverse events).
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In the control samples (cells without Pep-A), M1 population is 99.99 whereas the M2 population is 0.01; in the case of 50 µM of Pep-A, M1 population is 99.97, whereas the M2 population is 0.03.
Without Pep-7 interference, however, pRb was pulled down by His-HPV16E7 fusion protein (Figure 5B).
The cells were then treated with or without Pep-7 at 24 h post transfection for another 24 h before subjected to luciferase activities evaluation.
SiHa cells were treated with or without Pep-7 and then subjected to PI staining cell cycle analysis by flow cytometry as described in Materials and Methods.
In this study, SiHa, CaSki and HeLa cells were treated with or without Pep-7 at concentrations indicated in Figure 3.
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