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Possible cases required host factors, but without microbiological proof.
a. Septic shock requiring Pediatric Intensive Care Unit (PICU) admission with or without microbiological proof.
Clinically documented infection (e.g. CVL site infection, tunnel track infection, cellulitis, abscess formation at any site, typhlitis), with or without microbiological proof, requiring antibacterial or antifungal therapy beyond 48 hours.
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The first sample of each patient was collected after microbiological proof that STEC O104:H4 was present.
In this study, microbiological proof of infection was possible in about 67% of the patients.
All study participants (including those with evidence of concomitant extrapulmonary disease) had microbiological proof of pulmonary TB PTBB).
Restricting the analysis to include only patients with microbiological proof of infection did not alter these findings [ 24].
Diagnosis of TB was based either on microbiological proof or high clinical suspicion with favourable response to anti-TB treatment.
Stool was analysed for microbiological proof of STEC (Shiga toxin producing E. coli, O104:H4) for all patients with diarrhoea or bloody diarrhoea attending the University Medical Center Hamburg-Eppendorf during the outbreak.
As commonly reported in pneumococcal pneumonia, positive blood culture was found in 101 patients (45.5%), and was the single microbiological proof in 33 patients.
This is in good agreement with findings in large sepsis trials where microbiological proof was possible in 41 to 51% of the patients with airway infections [ 42, 43].
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