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Equilibrium points of the system without maturation delay and of that with maturation delay are the same, as time delay does not change the equilibria of the system.
The maturation experiment was performed with the following maturation pre-treatments: normal tap water, a 21.25 kg m−3 brine solution and without maturation.
Importantly, we demonstrate for the first time that MDDC infected with MVA and MVA-B, secrete IL-7 and IL-15 at levels more than 30-fold higher than the negative control after 48 h post-infection without maturation cocktail.
In particular, the levels of IL-7 and IL-15 obtained after MVA and MVA-B infection were approximately 100 fold higher than after mock-infection without maturation cocktail.
Bone marrow examination confirmed acute myeloid leukaemia (AML) without maturation (Fig. 1b).
We repeated hierarchical cluster analysis of all regulated genes in old WT mice without maturation adjustment revealing the same association of samples (see Additional file 3: Figure S3A).
Similar(49)
Studies on Tpo receptor describe that Jak2 stabilises the mature Tpo receptor on the cell surface without affecting maturation kinetics [19].
We were able to select well behaved and highly specific DARPins against a broad range of target proteins having affinities as low as 100 pM directly from this library, without affinity maturation.
The replication-competent NYVAC-C-KC virus showed enhanced antigen expression and presentation to HIV- and vaccinia-specific CD8 T cells without inducing maturation of (cross-presenting) dendritic cells.
Vpr downregulates the expression of costimulatory molecules on DC [ 9], whereas tat triggers IFN responsive gene expression in IDC without inducing maturation [ 11, 12].
For the experiments without schizont maturation, infected blood was resuspended to 2% hematocrit in MCM, spiked with CQ for 4 h, washed twice with 30 ml PBS and injected.
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