Sentence examples for without large changes from inspiring English sources
Put together, these data suggest that concerted changes in the conformation of specific residues facilitate the stabilization of nucleotide complexes thereby enabling the steps involved in the ping-pong reaction mechanism without large changes to the overall structure of this enzyme.
Striated muscle myosins are thought to have low duty cycles; thus doubling ton could produce the observed changes in force and velocity without large changes in total cycle time as measured by ATPase rates.
However, labor at 3,100 m generated greater ATP and ATP/ADP ratios, without large changes in glucose or lactate.
This may allow for a level of sequence diversity that can evade immune recognition without large changes to the protein structure [ 27].
Moreover, the substitution of the highly conserved Glu with Leu in ADH3 decreased catalytic efficiency by 3000-fold foxidationiof of (S -hydroxymethylglutathione, without large changeS -hydroxymethylglutathioneor binding of the coenzyme.
GP education for back pain that both includes health improvement methodologies and involves patients may yield additional benefits for some patients without large changes in patterns of practice activity.
In HFFs, strong decline already started after PD32 without larger changes for late PD.
Specifically, if the balance between slippage and point mutation favors point mutations within the repeated region, the mutations may interrupt the feature of the microsatellite without eliciting large changes in length.
But it also makes it that much more difficult for Twitter to make large changes without upsetting core constituents.
This paper outlined the potential for a freight service on board the metro, without the need for large changes to existing infrastructure or redevelopment of the network.
At low temperatures, the semi-IPN gel in the buffer solution was absolutely transparent; however, when the gel was heated, the gel became milky white or opaque without a large change in the gel size.
