Patients with 'pure' AMN had isolated spinal cord disease with or without adrenal insufficiency but without cerebral demyelinating lesions at brain MRI.
When limited to patients without renal insufficiency and ALI/ARDS patients without concomitant cardiac dysfunction (only 25% of their total cohort), the AUC improved to 0.86.
This result was confirmed in subgroup analyses of patients with and without diabetes and with and without renal insufficiency.
Finally, no significant differences of H2S, M66, and NO were found between patients with and without alcoholic pancreatitis as well as between patients with and without pancreatic insufficiency.
However, participants with hepatitis C without liver insufficiency could take part in the trial.
Suitable planned TEA decreases postoperative morbidity and mortality providing optimal analgesia without respiratory insufficiency [ 9].
When restricted to patients without renal insufficiency (41% of their cohort) the AUC improved to 0.82.
Post-mortem reports typically describe infants with normal growth and signs of acute anoxia without uteroplacental insufficiency.
Asymptomatic proteinuria without renal insufficiency was noted in 64% of patients in the high dose bevacizumab arm.
More recently, however, many more heterozygous NR5A1 mutations have been identified in patients with 46,XY DSD without adrenal insufficiency.
