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These sensitivity analyses included consideration whether conclusions would have differed if the eligibility was restricted to studies without high risk of bias versus all studies or if alternative imputation strategies were adopted, e.g., using odds ratio rather than risk ratio for the summary effect measure or a fixed effect rather than a random effects as the analysis model.
Multiple genes related to cardiovascular function and fatty acid metabolism have changed radically through mutations to permit a high-fat menu without high risk of heart disease, the researchers said.
Adjustment (when necessary) was achieved for 15 of the 21 studies, including all the studies without high risk of bias (see below).
In what we termed hereafter 'base case analysis', the models were fitted on the outcomes from the nine studies without high risk of bias.
When only considering studies without high risk of bias, the range stays the same, but the majority of studies shows an incidence between 0.20 and 0.25 (Table 1, Figure 2).
Nine studies were evaluated to be without high risk of bias in the reported incidence of symptomatic RV infections and 7 studies to be with high risk of bias (the reasons are presented in Table S3).
Similar(46)
Nevertheless, considering studies in a large cohort recently published, PD is now considered as a feasible dialysis method for most PKD patients without higher risk of infectious or mechanical complications [ 8– 10].
The pulmonary artery catheter should be used with the same scrutiny as any other diagnostic and monitoring tool used to diagnose disorders and adjust therapy in critically ill patients – patients without an actual hemodynamic problem or without a high risk of developing one should not receive a pulmonary artery catheter.
Opponents argue that the method cannot be used without a high risk of water contamination and other environmental hazards.
The challenge is finding the few that offer good yields but without a high risk of default.
The examples given in Section 7 show that the results can be analysed in a direct way, without the high risk of misinterpretation involved in the analysis of frequentist results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com