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"We are very skeptical of the approvability of solanezumab without further trials," Seamus Fernandez, an analyst at Leerink Swann, wrote Friday.
Some disappointing news for biotech drug developer Replidyne and drugmaker Forest Laboratories : The companies say the U.S. Food and Drug Administration will not approve faropenem medoxomil, their jointly developed antibiotic, without further trials.
So it is difficult to draw any conclusions about the effectiveness of olanzapine in patients undergoing multiday cisplatin chemotherapy without further trials.
The concerns about increased mortality with pre-referral rectal artesunate in older children and adults will not be resolved without further trials.
Larger improvement may be achieved when there is not the downward trend on scores that we observed in other wards in this study, but this cannot be known without further trials.
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As severe AD remains a disease without ideal management options, further trials of these medications are needed and warranted.
Seventeen trials excluded girls/ women, because of the difficulty separating stool from urine without a catheter, and seven further trials did not report on the sex of the study participants.
We also determined whether the level of spin in abstract conclusions was high (spin reported without uncertainty or recommendations for further trials), moderate (spin reported with some uncertainty or recommendations for further trials) or low (spin reported with uncertainty and recommendations for further trials).
The effect of a drug on a subgroup of patients in a trial is typically not sufficient grounds for a drug to be approved without further clinical trials involving just that subgroup.
This test was conducted in direct succession of the first experiment and without further training trials.
However, a previous Cochrane review did describe the maternal and neonatal outcome of the same clinical trial [ 9] we cited, and they stated that caesarean delivery of a non cephalic presenting twin B is associated with increased maternal morbidity but not with improved neonatal outcome, and that a policy of caesarean delivery should not be adopted without further controlled trials [ 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com