The storm's redevelopment again caught the Bureau of Meteorology off-guard, who had expected the storm to dissipate and move out to sea without causing further substantial damage.
This combination strategy, however, was without further significant effect on HRGβ1-induced AKT activity compared with the effects of gefitinib alone, and induced a substantial and significant enhancement of, rather than an inhibition of, HRGβ1-driven Tam-R cell invasion.
Mutational substitution of such Cys residues eliminates reactive buried thiols but cannot be accomplished simultaneously at all 3 positions without also introducing further substantial instability.
In the ADDITIONS study, the addition of ivabradine led to a further substantial reduction in resting heart rate without excessive bradycardia.
For me it is clear that, without strong foundations, the Union will not come through a further substantial enlargement unscathed.
(Assorted Prose, 1965, followed by several further substantial collections of criticism).
Further substantial costs are special education expenses.
With recent improvements in detector technology, automated exposure control techniques and iterative image reconstruction, a further substantial decrease in radiation exposure of 80% to a level around 0.2 mSv is possible without impairing image quality [ 56].
"The interest of the State of Florida and the victim's family in seeing that Schwab's sentence is carried out without further delay is substantial," the appellate panel wrote.
While they should be correctable without further experiments, a substantial rewrite will be required.
[Editors' note: the author responses to the first round of peer review follow.] We are confident that we have addressed the reviewers' concerns, without further experiments or substantial re-analysis of the data.
