Exact(5)
Results showed the probability of completing 5 cycles without emesis was 57%.
In the acute period, the proportion of patients without emesis in the L-752,298 and ondansetron groups was 37 and 52%, respectively.
In the delayed period, the proportion of patients without emesis in the L-758,298 and ondansetron treatment groups was 72 and 30%, respectively (P=0.005).
The primary efficacy parameters were the proportions of patients with no emesis and the proportion of patients without emesis or rescue therapy on day 1, and on days 2-5.
In the delayed phase, all three groups receiving L-745,030 had superior protection as compared with group I; the proportion of patients without emesis in groups I, II, III and IV was 29, 63, 51 and 57%, respectively, P<0.01 for groups II, III and IV vs group I.
Similar(54)
It does the job, and, considering that it was directed by the man responsible for "Mrs. Doubtfire," "Stepmom," and the "Home Alone" films, we should be grateful that it does so without inducing emesis.
Various brain areas are involved in nausea and emesis without there being a single 'emesis center'.
induced emesis without lethality upto the observation period.
Intermediate/high-dose cytarabine (≥1 gm/m) is considered to have moderate emetic risk according to recent oncology guidelines, with a 30%to90%0% risk of emesis without the use of prophylactic antiemetics [ 5].
A recent literature review confirmed that 5HT3 antagonists, with or without corticosteroids, achieved better emesis control than other antiemetic drugs.
Patients subsequently associate the hospital with nausea and vomiting: smells, sights, or thoughts of the hospital can then elicit emesis (the conditioned response) without the emetogenic agent.
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