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Locations without DST can instead use the first days of spring and autumn as reminders.
Patients with suspected MDR-TB but without DST results were categorized according to clinical and bacteriological criteria, and high-risk patients were started empirically on second-line TB drugs.
Without Dst the correlation coefficient is 0.982.
Analyses that include DST results exclude patients without DST results, which may cause a selection bias and the point estimates may be over or under-estimated due to the excluded cases.
Although the yield of positive cultures was high for all methods used (67.4% for indirect conventional DST, 78.5% for direct NRA, and 35.3% for largely paucibacillary or smear-negative samples submitted for BACTEC; data not shown), the contribution to relative risk of MDR TB among those without DST results could not be determined.
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Specimens submitted to the Mycobacteriology laboratory for mycobacterial culture with or without additional DST were processed according to WHO guidelines using the N-acetyl-L-cysteine-NaOH decontamination procedure and the Auramine-O technique for direct smear staining.
Advocates cite the same advantages as normal DST without the problems associated with the twice yearly time shifts.
In this cohort of patients, most patients were started empirically on second-line drugs, without waiting for DST results.
Nonetheless, DST without bacterial culturing will continue to require NAA.
LPA was performed without knowledge of conventional DST results.
Testing at the University laboratory was completely independent of testing in the FIND-NTRL laboratory and was performed without knowledge of conventional DST results.
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