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Without detailed understanding of the specific intention of a WTD, and without insight into its specific meanings, reasons and functions, it will be difficult to understand what a patient actually wants and why wishing it is important to her or him.
Use of absolute values without detailed understanding of the basis behind them can be misleading.
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Another is that the United States shouldn't go to war without a detailed understanding of the country we're entering, and the forces we're likely to empower.
But beyond that, some of the biggest breakthroughs in science could never have happened without a detailed understanding of the differences between species.
Small sub-basins are numerous in Mediterranean area and global sedimentary budgets cannot be obtained without a detailed understanding of the hydroclimatic processes that govern sediment fluxes in these small river systems.
The study demonstrated how the general information or data available can be incorporated in the model to produce useful qualitatively appreciable results, without requiring detailed understanding of the processes or comprehensive data records.
Interventions addressing barriers specifically are unlikely to influence policy without a detailed understanding of all these factors.
The reasons for this difference are hard to ascertain without a detailed understanding of what was included in the HR-MSM cost in that study.
However, without a detailed understanding of spatiotemporal enzyme activity and regulation of fatty acid production, engineering microbes to meet growing energy demands will be a considerable challenge.
The scores of the first principle components are used to generate meaningful plots without a detailed understanding of the underlying sample biochemistry.
Commercial development of nanotechnology and its many applications may unleash a spectrum of human health hazards that at the present time can only be speculated about without any detailed understanding of the toxic nature of NPs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com