Other therapeutic alternatives, such as TKIs pazopanib or sorafenib, mTOR inhibitor temsirolimus, VEGFR antibody bevacizumab, cytokine therapy with interferon- α, or clinical trials [ 2], could be provided, if there would be a possibility to distinguish individuals with and without benefit from sunitinib therapy.
Although conventional KRAS tests are useful to exclude patients without benefit from anti-EGFR therapy, response rates and disease control rates to anti-EGFR antibody monotherapy among patients with KRAS exon 2 wild-type tumors are only 13 17% and 51%, respectively [ 6, 7].
(I do know one person who took time out between high school and college without benefiting from financial support from parents, but he was from a country where undergraduate education was free).
Here we near the sublime: Brexit could amount simply to Britain losing its influence in Brussels, giving up its voice – basically, surrendering its sovereignty without benefiting from any shared sovereignty to limit the coming economic disaster.
Yet according to agency and court documents, even when blacks got such loans, they received less than requested, were forced to provide excessive collateral and had their applications processed too late in the planting season to do any good -- ensuring that black farmers would be in debt without benefiting from the money.
Yet — take it from the lady champ herself — tennis is still a man's game, and there is no queen of the courts as yet discovered who has defeated a prominent player of the opposite sex, in an exhibition or practice match without benefiting from unusual gallantry on the man's part.
To avoid having the cost of using the system without benefiting from it, due to low overall compliance, drivers may cease to comply themselves.
So too it is suboptimal for a retailer to try and review an item assortment optimization scheme, plan a store format or target a customer or shopper segment without benefiting from the manufacturer's expertise.
The former group are unlikely to be cured and may die early without benefiting from radical treatment.
In the Ghana GCP code [ 20], a clarification was added to the WHO/GCP definition, to clarify that an individual, company, institution or organization that provides money for a trial without benefiting from its results, is excluded from the definition of sponsor.
Furthermore, they find it unfair that their data are used to generate revenue by online services without their knowledge or without their benefit from this.
