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Benfotiamine alleviated diabetes-induced cerebral oxidative stress without affecting levels of AGE, protein carbonyl, tissue factor and TNF-α.
YW211.31 antibody inhibits Wnt3a-induced LRP6 phosphorylation and β-catenin protein stabilization without affecting levels of LRP6 protein, similar to purified Wnt-binding protein Fzd8CRD-Fc [21] and LRP6-binding protein DKK1 (Figure 1B).
Normalization of fasting glycemia by PIO was obtained without affecting levels of plasmatic insulin.
CerS2 knockdown upregulated KCa1.1 in the gastric SMCs of WT mice (Fig. 3D), without affecting levels of other CerS in gastric SMCs (Fig. S3C).
Incubation of 0 3 hr clarified embryo extracts with GFP-TRAP-A consistently depleted ∼95% of Mst-GFP, without affecting levels of untagged Mst, demonstrating that Mst is a monomer in the embryo.
Transfection of NB2a/d1 cells with a cocktail of shRNA (CDS1-4; Table 1) reduced synthesis and steady-state levels of NF-H, without affecting levels of the other NF subunits or actin (Fig. 1).
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This hormone ripens eggs in females and has long been thought to do the same for sperm--without affecting levels of the male sex hormone, testosterone.
We increased SM amount without significantly affecting levels of cholesterol/phospholipids or the viability of the cells (see Materials and Methods and Galvan et al, 2008).
Interestingly WA treatment significantly reduced IgE level without affecting IgG levels and also down-regulated the levels of pathogenic cytokines (IL-4, IL-13, IL-12 and IFN-γ) and chemokines (CCL17 and CCL22) involved in AD development.
Decitabine induced the demethylation of the PRKD1 promoter, and this correlated with the reexpression of PKD1 at the transcriptional level and at the protein level without affecting the levels of expression of PKD2 and PKD3.
In contrast, mutation or depletion of most other members of the SSU processome complexes causes decreased 18S rRNA levels without affecting the levels of the 25S or 5.8S rRNA.
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