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In contrast, the five cell lines without aberrant activation of PI3K signaling were all insensitive to the drug, even at concentrations greater than 10 µM, far exceeding those required for inhibition of Akt phosphorylation.
He also complained of paroxysmal headaches without aberrant palpitations, increased transpiration or paleness.
Patients with aberrant behaviours had several different characteristics to patients without aberrant behaviours.
Fetal human colon epithelial cells without aberrant Wnt signalling were transfected with wild-type or mutated MET constructs.
Therefore, we could not perform a survival analysis comparing patients with or without aberrant JAG1 or JAG2.
In addition, VC treatment also normalized the bone strength and composition of collagen cross-links, without aberrant bone modeling [ 21].
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After the first induction cycle, blasts were reduced to 5% in bone marrow without any aberrant profile in flow cytometry.
Similarly, UFT was effective for patients without p53 aberrant expression (5-year survival rates: 95.2% for the UFT group and 74.3% for the Control group, P = 0.022), whereas not effective for patients with p53 aberrant expression.
Both systemic and eye-drop application of MTP-131 early in the course of visual decline prevented further decline and fully reversed visual dysfunction without normalizing aberrant glucose clearance or hyperglycemia and weight.
Many of the genes found overexpressed without associated aberrant copy number are involved in maintenance of pluripotency (e.g. POU5F1 and NANOG) and are also highly expressed in PGCs (Almstrup et al, 2005).
The dose-dependent inhibition of TLR2 may help to explain why functioning NOD2 is able to handle commensal bacteria in the gastrointestinal tract, without the aberrant inflammation seen in NOD2 mutants.
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