He was, without a doubt, a firebrand.
Without a doubt, the toughest challenge faced by leaders during a turnaround is to avoid backsliding into dysfunctional routines habitual patterns of negative behavior by individuals and groups that are triggered automatically and unconsciously by familiar circumstances or stimuli.
Without a doubt, the biggest challenge in the study of the human plasma proteome is overcoming the detection problems associated with its large protein concentration range, which spans more than 10 orders of magnitude.
Without a doubt, science is challenging; the years involved in the completion of a PhD are full of difficulties.
"Without a doubt we have challenges, and in some cases things are going a little slower than we expect," Chernin said.
"Without a shadow of a doubt the biggest challenge has been half-time, having to communicate through a translator, it's the most frustrating thing," he said.
The Next Giant Leap team is without a doubt highly qualified for the challenge, but it will not be without tough competition, particularly from Astrobotic.
"Improving the performance of our health care system is without a doubt one of the most important challenges our nation faces," Mr. Bernanke said in remarks on health care changes organized by a Senate panel on Capitol Hill.
"You'd rather have a name like Moviefone than one like Fandango because that's what someone is going to plug into a search engine, but without a doubt, you are going to be challenged," said Allen P. Adamson, managing director of Landor Associates, a brand design firm.
These developments will without a doubt impose significant technical and economic challenges and opportunities on the chemical industry as a whole.
"It's a huge challenge without a doubt," he told BBC Radio Lancashire.
