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All of the isolates contained within this outbreak population, with the exception of two, were genomically indistinguishable (no probe set differences).
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Studies are in progress to characterize the neuraminidase, M2, and HA2 proteins to determine the molecular basis responsible for antigenicity differences observed within isolates from this outbreak.
The 2 possible explanations for the source of the virus that caused the 2005 monkeypox outbreak in Sudan are 1) the existence of conditions permitting the long-term maintenance of MPXV in wildlife within the area where this outbreak occurred and transmission of the virus from reservoir hosts into humans; and 2) the importation of MPXV into the outbreak area by an infected human or animal.
This outbreak had two peaks within the year and a mortality of 75%.
There are no longitudinal studies assessing the per-cohort MDV outbreak probability, so these model predictions serve as the first published estimates of MDV within-barn outbreak risk.
Transmission was less likely to occur in lowland compared with hill flocks, while keeping crossbred Texel ewes was associated with a decreased risk of a within-flock outbreak.
Modelling studies, however, suggest that the frequency of PrP genotypes will be a significant factor in a within-flock outbreak of scrapie [ 25, 26].
Three environmental isolates were located within the outbreak cluster.
Both strains were located within the outbreak cluster in the phylogenetic tree.
CP sourced from within the outbreak is the most readily available source of anti-EVD antibodies.
> > -wrap-foot> Nothely, the mean SNP variation within the outbreak isolates is only 17 SNPs.
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