This interlocked structure is held together primarily, if not entirely, by the interactions of the DID domains of each N-terminal dimer with the DAD domains emanating from the more distal FH2 dimer.
This interlocked tight dimer is a novel structural feature that we named Implico, from Latin to entangle.
31 Encouraged by the crystallographic evidence that the chloride counteranion is encapsulated within the interlocked binding cavity of the [2]catenane 16⋅Cl in the solid state, we employed H NMR, UV/Vis and fluorescence spectroscopic titration experiments to investigate the ability of the [2]catenane host system to recognise and sense halide anions in solution.
This shortcoming, however, should not detract from the usefulness of this open interlocked intramedullary nailing technique.
To this end, interlocked intramedullary nailing combines the biomechanical advantages of nailing with some of the anti-rotation ability of plate and screws but without the associated impairment to the periosteal blood supply.
Instead of average statistical information obtained from an ensemble of species, these techniques allow direct measurement of molecular level forces, mechanical properties and motions such as rotation, gliding, and translation, pivoting of an individual molecule, supramolecular host guest exchange, and coconformational changes within interlocked molecular assemblies.
Our group 13 and others 14 have demonstrated that anions can also be effectively employed as discrete interweaving templates during catenane synthesis, and that the preorganised three-dimensional binding pockets contained within the resultant interlocked architectures can subsequently be exploited for selective anion-recognition purposes.
Wilson worked within this tradition.
Swiftly, within this amber and frozen air,.
Everything, within this framework, becomes an encounter.
